The role of endothelin-1 and its autoantibodies in the pathogenesisof atopic dermatitis: a case-control study

Background. Atopic dermatitis is a chronic multifactorial dermatosis with complex pathophysiological basis. One of the poorly studied links in pathogenesis disease endothelin-1. Its main biological effects include pronounced vasoconstriction blood vessels.
 Aim. To study role endothelin-1 and its autoantibodies atopic dermatitis.
 Materials methods. The included 40 patients common limited forms period exacerbation remission. concentration to it serum was determined by ELISA method. Statistical processing obtained data performed using Statistica 6.0. significance at p 0.05.
 Results. High concentrations were during disease. When clinical picture resolved; significantly decreased; but remained higher than control group. Based on obtained; can be assumed that an increase may marker white dermographism regulator microcirculation process skin.
 Conclusions. A high level contributes development inflammatory reactions skin; itching. Endothelin-1 receptors potential aim for targeted therapy dermatitis.